I do all my dev inside docker/orbstack environments. I've been using a Tailscale sidecar for each, which has let me easily spin up second (and third!) copy of each repo without having to worry about them interfering with each other (the same open ports etc.). I've not extended to using worktrees, as right now I prefer entirely separate clone's of a repo, but that may well change and I suspect this would work well for that too.
Also has the handy effect of making it super easy to share my dev environment with anyone else on my tailnet, though this could be locked down if needed.
I recently learned of OrbStack and it feels like the only product that actually makes an effort to integrate VMs and Containers correctly and consistently into macOS.
Docker Desktop and Podman Desktop are both a treadmill made of Lego bricks.
Have you tried Apple's container CLI[0]? I'm still mostly using OrbStack, but container gives me some hope for the future that Apple cares about this experience.
I use tailscale with Orbstack so that my agents on the vm can use tailscale serve to share dashboards I can view on my phone. Works out nicely.
One thing I noticed though, is that even if I set up the VM as a tagged device with limited access rules, if my host machine (the laptop) is connected as my user (which has less limited permissions), the vm uses my host's user permissions, which isn't really what I want. If I disconnect tailscale on the mac and leave the vm tailscale connected it works as intended though - so that's something to look out for.
Also, if you're using orbstack as an agent sandbox, just be aware that they only recently added an option for true filesystem isolation, the default setup doesn't really sandbox effectively.
https://robgough.net/multiple-app-instances-with-tailscale
Also has the handy effect of making it super easy to share my dev environment with anyone else on my tailnet, though this could be locked down if needed.
Docker Desktop and Podman Desktop are both a treadmill made of Lego bricks.
Have you tried Apple's container CLI[0]? I'm still mostly using OrbStack, but container gives me some hope for the future that Apple cares about this experience.
[0]: https://github.com/apple/container
One thing I noticed though, is that even if I set up the VM as a tagged device with limited access rules, if my host machine (the laptop) is connected as my user (which has less limited permissions), the vm uses my host's user permissions, which isn't really what I want. If I disconnect tailscale on the mac and leave the vm tailscale connected it works as intended though - so that's something to look out for.
Also, if you're using orbstack as an agent sandbox, just be aware that they only recently added an option for true filesystem isolation, the default setup doesn't really sandbox effectively.